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Lysle, D.T., Coussons, M.E., Watts, V.J., Bennett, E.H. and Dykstra, L.A. (1993) Morphine-induced alterations of immune status: Dose dependency, compartment speci-ficity and antagonism by naltrexone. Journalof Phar- macology and Experimental Therapeutics, 265(3), 1071- 1078.

has been cited by the following article:

• TITLE: Heroin-induced changes of CD34-positive rat thymus cells

  AUTHORS: Gentimi Fotini, Perrea Despina, Marinos Evangelos, Konstandi Ourania, Katsorchis Theodoros

  KEYWORDS: Heroin; Rat Thymus; CD34

  JOURNAL NAME: Health, Vol.2 No.8, August 26, 2010

  ABSTRACT: Heroin is a well known opioid that causes al-terations to the immune system of a number of investigated animals. Only a few studies have explored the effect of heroin on the lymphocytes maturation. Thymocyte progenitors originate from haematopoietic stem cells in the bone marrow. The immature T-cells express neither CD4 nor CD8, and are therefore classed as double-negative (CD4-CD8-) cells. CD34 glycoprotein is the only defined marker of the immature T-lymphocytes. In this study we have investigated the changes induced in CD34+ rat thymocytes after heroin administration by immunofluores-cence in frozen rat thymus sections using the 4H11 monoclonal anti-CD34 antibody. There is a remarkable decrease in the number of CD34+ immature thymocytes when examined 1hour after last heroin injection and a small recover when examination took place 20 days after last injection. The above results suggest a major effect of heroin administration early in the ma- turation process of T lymphocytes probably by increasing the apoptotic cell death and the ne- gative consequences for the immune system responses.