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T. C. Walser, S. Rifat, X. Ma, N. Kundu, C. Ward, O. Goloubeva et al., “Antagonism of CXCR3 Inhibits Lung Metastasis in a Murine Model of Metastatic Breast Cancer,” Cancer Research, Vol. 66, No. 15, 2006, pp. 7701- 7707. doi:10.1158/0008-5472.CAN-06-0709

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• TITLE: Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas. Its Correlation with Chemokine MIG/CXCL9

  AUTHORS: Graciela Laguens, Silvia Coronato, Jorge Chambó, Vanda Di Girolamo

  KEYWORDS: Breast Cancer; CD4+ T cells; CD8+ T Cells’ MIG/CXCL9; Chemokines

  JOURNAL NAME: Advances in Breast Cancer Research, Vol.1 No.2, July 24, 2012

  ABSTRACT: The interaction between some chemokines with tumoral and stromal cells can influence tumor progression. CXCL9, a monokine induced by interferon gamma (MIG), targets lymphocytes.The aim of our study was to identify and quantify CD4+ and CD8+ T cells in the stroma of human breast cancer and correlate them with the presence of MIG/CXCL9. In 58 specimens of human breast carcinoma and 10 normal breast tissue from mammoplasty surgery, immunohistochemistry and ELISA methods were performed. The number of CD4+ and CD8+ T cells in breast cancer tissue was significantly increased compared with normal breast tissue with a clear predominance of CD8+ T cells. MIG/CXCL9 levels were significantly elevated respect normal breast tissue. This chemokine correlated with the number of CD8+ T cells only in non-metastatic tumors. These data suggest that MIG targets cytotoxic T cells. Their recruitment into breast carcinoma can play a critical role in malignant progression, inhibiting the production of metastasis.