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Ferrari, R., Ceconi, C., Curello, S., Cargnoni, A., Alfieri, O., Pardini, A., Marzollo, P. and Visioli, O. (1991) Oxy-gen free radicals and myocardial damage: protective role of thiol-containing agents. The American Journal of Medicine, 91(3), 95S-105S.

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• TITLE: Apelin-12 improves metabolic and functional recovery of rat heart after global ischemia

  AUTHORS: Oleg I. Pisarenko, Valentin S. Shulzhenko, Yulia A. Pelogeykina, Irina M. Studneva, Denis N. Khatri

  KEYWORDS: Apelin-12, Rat Heart; Ischemia/ Reperfusion Injury; Energy Metabolism; Cell Membrane Damage

  JOURNAL NAME: Health, Vol.2 No.8, August 26, 2010

  ABSTRACT: This work was designed to explore efficacy of apelin-12 (A-12) as a cardioprotective agent when given before ischemia or at reperfusion using the isolated working heart model. Hearts of male Wistar rats were subjected to 30-min stabilization period followed by 35-min global ischemia and 30-min reperfusion. A short-term infusion of Krebs-Henseleit buffer (KHB) con-taining A-12 (35, 70, 140, 280 or 560 ?M) was ap-plied prior to ischemia (A-12-I) or at onset of reperfusion (A-12-R). KHB infusion was used as control. A-12 infusions induced a dose-dependent increase in recovery of coronary flow, contractile and pump function during reperfu-sion, with the largest augmentation of these indices in the A-12-I group. Both A-12 groups exhibited a significant reduction of LV diastolic pressure rise during reperfusion compared with control. Enhanced functional recovery in the A-12-I group was combined with a decrease in LDH leakage in perfusate on early reperfusion (by 36% vs. control, p