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Tatemoto, K., Hosoya, M., Habata, Y., Fujii, R., Kake-gawa, T., Zou, M. X., Kawamata, Y., Fukusumi, S., Hinuma, S., Kitada, C., Kurokawa, T., Onda, H. and Fu-jino, M. (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochemical and Biophysical Research Communications, 251(2), 471-476.

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• TITLE: Apelin-12 improves metabolic and functional recovery of rat heart after global ischemia

  AUTHORS: Oleg I. Pisarenko, Valentin S. Shulzhenko, Yulia A. Pelogeykina, Irina M. Studneva, Denis N. Khatri

  KEYWORDS: Apelin-12, Rat Heart; Ischemia/ Reperfusion Injury; Energy Metabolism; Cell Membrane Damage

  JOURNAL NAME: Health, Vol.2 No.8, August 26, 2010

  ABSTRACT: This work was designed to explore efficacy of apelin-12 (A-12) as a cardioprotective agent when given before ischemia or at reperfusion using the isolated working heart model. Hearts of male Wistar rats were subjected to 30-min stabilization period followed by 35-min global ischemia and 30-min reperfusion. A short-term infusion of Krebs-Henseleit buffer (KHB) con-taining A-12 (35, 70, 140, 280 or 560 ?M) was ap-plied prior to ischemia (A-12-I) or at onset of reperfusion (A-12-R). KHB infusion was used as control. A-12 infusions induced a dose-dependent increase in recovery of coronary flow, contractile and pump function during reperfu-sion, with the largest augmentation of these indices in the A-12-I group. Both A-12 groups exhibited a significant reduction of LV diastolic pressure rise during reperfusion compared with control. Enhanced functional recovery in the A-12-I group was combined with a decrease in LDH leakage in perfusate on early reperfusion (by 36% vs. control, p