TITLE:
Rare Tumors of Ovary: Case Report and Literature Review
AUTHORS:
El Fatemi Hinde, Hammas Nawal, Saadi Hannane, Brahmi Sami, Amarti Afaf, Bannani Abdelaziz, Mesbahi Omar
KEYWORDS:
Ovary; Neuroendocrine Carcinoma; Non-Small Cell Type; Serous Carcinoma; Immunohistochemistry
JOURNAL NAME:
Open Journal of Pathology,
Vol.2 No.3,
July
18,
2012
ABSTRACT: Introduction: Large cell neuroendocrine carcinoma (LCNEC) or non small cell neuroendocrine carcinoma the ovary is a rare entity and is frequently associated with ovarian surface epithelial tumors. However, its association with serous carcinoma is rarer, in our knowledge tree cases has been described in international literature and the first case in Moroccan literature. Case Report: A 54-year-old woman presented with a pelvic mass measuring 15 cm in diameter. She underwent an exploratory laparotomy with resection of the pelvic mass. Diffuse and nodular intra-abdominal disseminations were observed. Immunohistochemistry stain confirmed the diagnosis of large cell neuroendocrine carcinoma with serous carcinoma. The patient received three courses of carboplatin and paclitaxel and she's still alivewith a decline of 6 months. Its clinicopathologic association is discussed and the literature is reviewed. Conclusion: In summary, ovarian LCNEC is an aggressive tumor with a tendency to present at advanced stage and cause death within a mean of 17 months after diagnosis; however, some patients, particularly those with stage I disease and/or those who have received platinum-based therapy, may have a more favorable prognosis.