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A. G. Siebers, P. J. Klinkhamer, J. M. Grefte, L. F. Massuger, J. E. Vedder, A. Beijers-Broos, J. Bulten and M. Arbyn, “Comparison of Liquid-Based Cytology with Conventional Cytology for Detection of Cervical Cancer Precursors: A Randomized Controlled Trial,” JAMA, Vol. 302, No. 16, 2009, pp. 1757-1764. doi:10.1001/jama.2009.1569

has been cited by the following article:

• TITLE: Use of Liquid-Based Cytology (LBC) and Cell Blocks from Cell Remnants for Cytologic, Immunohistochemical, and Immunocytochemical Diagnosis of Malignancy

  AUTHORS: Hirofumi Sakamoto, Makiyo Takenaka, Kazuki Ushimaru, Takuji Tanaka

  KEYWORDS: LBC; Cell Remnants; Cell Block; Immunohistohemistry; Immunocytochemistry; Biomarkers; Cancer; Accurate Diagnosis

  JOURNAL NAME: Open Journal of Pathology, Vol.2 No.3, July 18, 2012

  ABSTRACT: Great advances in screening have lowered the death rate from cervical cancer in the advanced countries. The major advances in cervical cancer screening include the Papanicolaou (Pap) test and liquid-based cytology (LBC). In this study, we aimed to use cell remnants from LBC specimens from uterine cervix and endometrium, aspirates from breast and thyroid tumors, and liquid samples (ascites, pleural effusion, and urine). Cell blocks made from cell remnants of LBC specimens were immunohistochemically or immunocytochemically stained for several biomarkers including certain tumor markers such together with hematoxylin and eosin staining for accurate diagnosis of malignancies in different samples. The findings from the cell blocks stained with these biomarkers combined with those from Pap stain led to easily diagnosis of the presence or absence of malignancies. Our findings suggest the utility of LBC and cell blocks from cell remnants in cytologic diagnosis in certain specimens.