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Seydel, J.K. and Wiese, M. (2002) Drug-membrane interactions, analysis, drug distribution, modeling. In: Mannhold, R., Kubinyi, H. and Folkers, G., Eds., Methods and Principles in Medicinal Chemistry, Wiley-VCH Verlag GmbH, Weinheim, 15.

has been cited by the following article:

• TITLE: Approaching intermolecular interactions and membrane activity of taxol by FTIR Spectroscopy-implications for anticancer therapeutics

  AUTHORS: Erhan Erhan Süleymanoglu

  KEYWORDS: Antineoplastic Drugs; Taxol-Membrane Interactions; Structural Changes; FTIR Spectroscopy

  JOURNAL NAME: Health, Vol.2 No.8, August 25, 2010

  ABSTRACT: We studied the incorporation of hydrophobic drug Taxol into a solid lipid matrices by FTIR spectroscopy. Lipid arrays containing different molar fractions of the drug were made and deposited on the spectrometer glass window substrates for obtaining multilayer stacks. The drug induced an alteration of lipid array spacings, indicating the drug-lipid recognition. Using excess amounts of Taxol provide information on extrapolations on its cellular solubility in biomembranes. The data obtained could be used further for developing novel anticancer drug formulations, as well as for elucidating its novel cellular pharmacological targets.