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S. M. Pikkujamsa, T. H. Makikallio, L. B. Sourander, I. J. Raiha, P. Puukka, J. Skytta, C. K. Peng, A. L. Goldberger and H. V. Huikuri, “Cardiac Interbeat Interval Dynamics from Childhood to Senescence: Comparison of Conventional and New Measures Based on Fractals and Chaos Theory,” Circulation, Vol. 100, No. 4, 1999, pp. 393-399. doi:10.1161/01.CIR.100.4.393

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• TITLE: Differences of Heart Rate Variability during Sevoflurane Anesthesia in Children by Age

  AUTHORS: Yong-Hee Park, Chang-Hoon Koo, Jin-Tae Kim, Hee-Soo Kim, Hyo-Jin Byon

  KEYWORDS: Children; Heart Rate Variability; Sevoflurane

  JOURNAL NAME: Open Journal of Anesthesiology, Vol.2 No.3, July 3, 2012

  ABSTRACT: Background: The child’s central nervous system develops with aging, and heart rate variability (HRV), which is con-trolled by the brain, differs from that of adults. We investigated changes in HRV during sevoflurane anesthesia in children. Methods: One 138 children aged from 2 - 12 years without major underlying problems were enrolled. During maintenance with 2 - 2.5 vol% sevoflurane anesthesia, electrocardiographic data were obtained and power spectral analysis, approximate entropy (ApEn) or Hurst exponent were analyzed and compared in three groups (age 2 - 5 years, 6 - 9 and 10 - 12 years of age). Results: The RR interval increased with aging, but low-frequency powers did not. High- frequency power was greater in the oldest children (P