Article citationsMore>>

C. Therapontos, L. Erskine, E. R. Gardner, F. D. William, N. Vargesson, “Thalidomide Induces Limb Defects by Preventing Angiogenic Outgrowth During Early Limb Formation,” Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 21, 2009, pp. 8573-8578. doi:10.1073/pnas.0901505106

has been cited by the following article:

• TITLE: Anesthetic Management of a Parturient with Thalidomide Phocomelia

  AUTHORS: Samuel N. Blacker, Tiffany E. Angelo

  KEYWORDS: Anesthesia; Thalidomide Phocomelia; Obstertric Anesthesia

  JOURNAL NAME: Open Journal of Anesthesiology, Vol.2 No.3, July 4, 2012

  ABSTRACT: The teratogenicity of thalidomide has been known since the early 1960s [1]. Thalidomide is currently used world wide, including the United States, to treat erythema nodosum leprosum, multiple myeloma, refractory Crohn’s disease, aphthous stomatitis and HIV wasting syndrome. New cases of thalidomide phocomelia are being reported as well. We report a case of the anesthetic challenges of a 23 year-old parturient with thalidomide phocomelia and review the important anesthetic challenges it presents. Spontaneous vaginal delivery under continuous lumbar epidural was achieved in this challenging patient. However, it required careful planning for reliable intravenous access and the use of magnetic resonance imaging (MRI) of her pelvis and lumbar spine.