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Jou?en, N., Heckel, D.G., Haas, M., Schuphan, I. and Schmidt, B. (2008) Metabolism of imidacloprid and DDT by P450 CYP6G1 expressed in cell cultures of Nicotiana tabacum suggests detoxification of these insecticides in Cyp6g1-overexpressing strains of Drosophila melanogaster, leading to resistance. Pest Management Science, 64, 65-73.

has been cited by the following article:

• TITLE: The genetic architecture of insecticide resistance within a natural population of Drosophila melanogaster

  AUTHORS: Takahiro Miyo

  KEYWORDS: DDT; Drosophila melanogaster; Genetic Variation; Insecticide Resistance; Permethrin

  JOURNAL NAME: Open Journal of Genetics, Vol.2 No.2, June 28, 2012

  ABSTRACT: The dynamics of genetic variation in susceptibility to insecticides within a natural population of Drosophila melanogaster (Meigen) at Katsunuma (Yamanashi Prefecture, Japan) was examined. Two resistance factors for three organophosphate insecticides (OPs), a resistant-type acetylcholinesterase (AChE) and a cytochrome P450 monooxygenase (cytochrome P450), have already been suggested to be involved within the Katsunuma population. In this study, genetic variances were estimated for susceptibility to other classes of chemicals than OPs, permethrin (a pyrethroid) and dichloro-diphenyl-trichloroethane (DDT; an organo-chlorine), which existed simultaneously with genetic variances for susceptibility to OPs. Analyses of variance for susceptibility to permethrin and DDT showed highly significant variation among isofemale lines from the Katsunuma population, and the genetic variances for susceptibility to each insecticide fluctuated differently during this period. The impacts of fluctuations of genetic variation in susceptibility to one class of insecticides on genetic variation in susceptibility to other classes of insecticides existing simultaneously within the natural population were discussed.