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J. Valderrama, A. Fournet, C. Valderrama, S. Bastias, C. Astudillo, A. Rojas de Arias, A. Inchausti and G. Yaluff, “Synthesis and in Vitro An-tiprotozoal Activity of Thio- phene Ring-Containing Quinones,” Chemical & Pharma- ceutical Bulletin, Vol. 47, No. 9, 1999, pp. 1221-1226. doi:10.1248/cpb.47.1221

has been cited by the following article:

• TITLE: The Reaction of 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophenes with Benzoyl-Isothiocyanate: Synthesis of Annulated Thiophene Derivatives and Their Antitumor Evaluations

  AUTHORS: Karam Ahmed El-Sharkawy, Hend Mohamed El-Sehrawi, Rehab Ali Ibrahim

  KEYWORDS: Tetrahydrobenzo[b]thiophene; Pyrimidine; Thiourea; Antitumor Activity

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.2 No.2, June 27, 2012

  ABSTRACT: The reaction of the tetrahydrobenzo[b]thiophene derivatives 1a,b with benzoylisothiocyanate (2) afforded the thiourea derivatives 3a,b. Cyclization of the latter products gave the annulated products 4a,b. Compounds 3a,b reacted with either hydrazine hydrate (5a) or phenyl hydrazine (5b) afforded compounds 7a-d which underwent cyclization for compounds 7a,c afforded compound 9. On the other hand compounds 4a,b reacted with either hydrazine hydrate (5a) or phenyl hydrazine (5b) afforded compounds 6a-d a second pathway was applied to synthesize compound 6c which underwent cyclization afforded compound 9. Also compounds 4a,b reacted with either phenacyl bromide (10) afforded compounds 11a,b or ethylchloroacetae (12) compounds 13a,b were produced. The latter products reacted with each hydrazine hydrate (5a) and phenyl hydrazine (5b) afforded compounds 14a-d. Their antitumor activities were tested using three different cell lines.