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Wolday, D., Tegbaru, B. ,Kassu, A., et al. (2005) Expression of chemokine receptors CCR5 and CXCR4 on CD4+ T cells and plasma chemokine levels during treatment of active tuberculosis in HIV-1-coinfected patients. Journal of Acquired Immune Deficiency Syndrome, 39, 265-271. doi:10.1097/01.qai.0000163027.47147.2e

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• TITLE: CD38 expression on CD8+ cells—Its influence on development of tuberculosis in HIV positive individuals

  AUTHORS: Ramaseri Sunder Sharada, Hanumanth Surekha Rani, Satya Sudheer Pydi, Jonnalagada Subbanna, Vijaya lakshmi Valluri

  KEYWORDS: HIV-TB; CD38; CD8; CD4; Viral Load

  JOURNAL NAME: Open Journal of Immunology, Vol.2 No.2, June 22, 2012

  ABSTRACT: CD38 expression on CD8+ cells seems to correlate well with HIV viral-loads, while the ex-pression levels are thought to be low in patients with tuberculosis. This study aimed at determining the levels of CD38 expression in HIV+ individuals who develop tuberculosis. Expression levels of CD8 and CD38 were analysed in peripheral blood collected from HIV (73), TB (32), HIV-TB (31) and healthy controls (20). The percentage of CD8+/CD38+ cells significantly increased during the first few years of seropositivity and decreased during 5 - 6 years. A decline in the expression of CD38, especially on CD8+ cells in a HIV+ individual within first 2 years of seropositivity, may be indicative of susceptibility to tuberculosis. This observation was reiterated when two patients developed TB during follow-up. CD38 on CD8 cells could perhaps be useful as an early biomarker for tuberculosis in HIV-positive individuals.