TITLE:
Paediatric amitriptyline overdose
AUTHORS:
Steve Doherty, Grant Cave, Martyn Harvey
KEYWORDS:
Tricyclic Anti-Depressants; Toxicity;Overdose
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.2 No.2,
June
19,
2012
ABSTRACT: We report a near fatal case of paediatric amitriptyline overdose including a series of ECGs demonstrating the effects of sodium bicarbonate therapy on cardio-toxicity. We briefly discuss the role of sodium to counteract the sodium channel blockade of tricyclic antidepressants and discuss the possible utility of lipid emulsion therapy in such cases.