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F. M. Ho, C. C. Lai, L. J. Huang, T. C. Kuo, C. M. Chao and W. W. Lin, “The Anti-Inflammatory Carbazole, LCY-2-CHO, Inhibits Lipopolysaccharide-Induced Inflammatory Mediator Expression through Inhibition of the p38 Mitogen-Activated Protein Kinase Signaling Pathway in Macrophages,” British Journal of Pharmacology, Vol. 141, No. 6, 2004, pp. 1037-1047. doi:10.1038/sj.bjp.0705700

has been cited by the following article:

• TITLE: Anti-Inflammatory Effect of 3-Methylcarbazoles on RAW 264.7 Cells Stimulated with LPS, Polyinosinic-Polycytidylic Acid and Pam3CSK

  AUTHORS: Thongchai Taechowisan, Srisakul Chanaphat, Wanwikar Ruensamran, Waya S. Phutdhawong

  KEYWORDS: 3-Methylcarbazoles; Anti-Inflammatory Activity; RAW 264.7 Cells, Streptomyces sp.

  JOURNAL NAME: Advances in Microbiology, Vol.2 No.2, June 13, 2012

  ABSTRACT: In the present study, 3-methylcarbazole and 1-methoxy-3-methylcarbazole were isolated from the culture of Streptomyces sp. LJK109, endophyte of Alpinia galanga Swartz. 3-methylcarbazole, a carbazole derivative, has been found to be highly potent as anti-inflammatory agent. The immunomodulatory activity of these agents in toll like receptor (TLR)-activated RAW 264.7 macrophages induced by lipopolysaccharide (LPS), Poly(I:C), and pam3CSK was investigated by assessing nitric oxide (NO) and pro-inflammatory cytokines. The 3-methylcarbazoles dose-dependently suppressed the release of NO, PGE2, TNF-α, IL-1β, IL-6 and IL-10 in LPS- and pam3CSK-activated macrophages but not in Poly(I:C)-activated macrophages. Our results suggest that 3-methylcarbazoles can be further developed as a promising anti-inflammatory remedy.