Article citationsMore>>

U. F. Castillo, G. A. Strobel, E. J. Ford, W. M. Hess, H. Porter, J. B. Jenson, H. Albert, R. Robison, M. A. Condron, D. B. Teplow, D. Stevens and D. Yever, “Munumbicins, Wide-Spectrum Antibiotics Produced by Streptomyces NRRL 30562, Endophytic on Kennedia nigriscans,” Microbiology, Vol. 148, No. 9, 2002, pp. 2675-2685.

has been cited by the following article:

• TITLE: Anti-Inflammatory Effect of 3-Methylcarbazoles on RAW 264.7 Cells Stimulated with LPS, Polyinosinic-Polycytidylic Acid and Pam3CSK

  AUTHORS: Thongchai Taechowisan, Srisakul Chanaphat, Wanwikar Ruensamran, Waya S. Phutdhawong

  KEYWORDS: 3-Methylcarbazoles; Anti-Inflammatory Activity; RAW 264.7 Cells, Streptomyces sp.

  JOURNAL NAME: Advances in Microbiology, Vol.2 No.2, June 13, 2012

  ABSTRACT: In the present study, 3-methylcarbazole and 1-methoxy-3-methylcarbazole were isolated from the culture of Streptomyces sp. LJK109, endophyte of Alpinia galanga Swartz. 3-methylcarbazole, a carbazole derivative, has been found to be highly potent as anti-inflammatory agent. The immunomodulatory activity of these agents in toll like receptor (TLR)-activated RAW 264.7 macrophages induced by lipopolysaccharide (LPS), Poly(I:C), and pam3CSK was investigated by assessing nitric oxide (NO) and pro-inflammatory cytokines. The 3-methylcarbazoles dose-dependently suppressed the release of NO, PGE2, TNF-α, IL-1β, IL-6 and IL-10 in LPS- and pam3CSK-activated macrophages but not in Poly(I:C)-activated macrophages. Our results suggest that 3-methylcarbazoles can be further developed as a promising anti-inflammatory remedy.