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U. F. Castillo, J. K. Harper, G. A. Strobel, J. Sears, K. Alesi, E. J. Ford, J. Lin, M. Hunter, M. Maranta, H. Ge, D. Yaver, J. B. Jenson, H. Porter, R. Robison, D. Millar, W. M. Hess, M. A. Condron and D. B. Teplow, “Kakadumycins, Novel Antibiotics from Streptomyces NRRL 30566, an Endophyte of Grevillea pteridifolia,” FEMS Microbiology Letters, Vol. 224, No. 2, 2003, pp. 183-190. doi:10.1016/S0378-1097(03)00426-9

has been cited by the following article:

• TITLE: Anti-Inflammatory Effect of 3-Methylcarbazoles on RAW 264.7 Cells Stimulated with LPS, Polyinosinic-Polycytidylic Acid and Pam3CSK

  AUTHORS: Thongchai Taechowisan, Srisakul Chanaphat, Wanwikar Ruensamran, Waya S. Phutdhawong

  KEYWORDS: 3-Methylcarbazoles; Anti-Inflammatory Activity; RAW 264.7 Cells, Streptomyces sp.

  JOURNAL NAME: Advances in Microbiology, Vol.2 No.2, June 13, 2012

  ABSTRACT: In the present study, 3-methylcarbazole and 1-methoxy-3-methylcarbazole were isolated from the culture of Streptomyces sp. LJK109, endophyte of Alpinia galanga Swartz. 3-methylcarbazole, a carbazole derivative, has been found to be highly potent as anti-inflammatory agent. The immunomodulatory activity of these agents in toll like receptor (TLR)-activated RAW 264.7 macrophages induced by lipopolysaccharide (LPS), Poly(I:C), and pam3CSK was investigated by assessing nitric oxide (NO) and pro-inflammatory cytokines. The 3-methylcarbazoles dose-dependently suppressed the release of NO, PGE2, TNF-α, IL-1β, IL-6 and IL-10 in LPS- and pam3CSK-activated macrophages but not in Poly(I:C)-activated macrophages. Our results suggest that 3-methylcarbazoles can be further developed as a promising anti-inflammatory remedy.