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P. Boon, K. Vonck, V. De Herdt, A. Van Dycke, M. Goethals, L. Goossens, M. Van Zandijcke, T. De Smedt, I. Dewaele, R. Achten, W. Wadman, F. Dewaele, J. Caemaert and D. Van Roost, “Deep Brain Stimulation in Patients with Refractory Temporal Lobe Epilepsy,” Epilepsia, Vol. 48, No. 8, 2007,pp.1551-1560. doi:10.1111/j.1528-1167.2007.01005.x

has been cited by the following article:

• TITLE: Effect of Unilateral Low-Frequency Stimulation of Hippocampus on Rapid Kindling—Induced Seizure Development in Rats

  AUTHORS: Lucas Toibaro, Magdalena Pereyra, Julieta Pastorino, Ariela Smigliani, Florencia Ocariz, Germán Ortmann, María Milagros Galardi, María Belén Gori, Silvia Kochen

  KEYWORDS: Hippocampal Rapid Kindling; Epilepsy; Electrical Stimulation; Low-Frequency Stimulation; Electrical Stimulation Protective Effect

  JOURNAL NAME: Neuroscience and Medicine, Vol.3 No.2, June 12, 2012

  ABSTRACT: Since the last decade deep brain stimulation has been proposed as an alternative treatment for patients who do not become seizure-free with the current pharmacological treatments and cannot undergo resective surgical procedure. However, the optimal stimulation parameters remain undetermined and active research in humans and animals is necessary. The present study was designed to investigate the effect of unilateral Low Frequency Stimulation (LFS) of hippocampus on seizure development by using the hippocampal rapid kindling method (hRK) in rats. We used male Wistar rats implanted with electrodes in the ventral hippocampus. All rats underwent hRK (biphasic square wave pulses, 20 Hz for 10 seconds) during three consecutive days (twelve stimulations per day). The control group (hRK; n = 6) received only RK stimulus, while the treated group (LFS-hRK; n = 8) received also LFS (biphasic square wave pulses, 1 Hz for 30 seconds) immediately before the RK stimulus, during three consecutive days. At the end of behavioral testing on day 3, 62% (P