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Robinson, C.P., Brayer, J., Yamachika, S., Esch, T.R., Peck, A.B., Stewart, C.A., Peen, E., Jonsson, R. and Humphreys-Beher, M.G. (1998) Transfer of human serum IgG to nonobese diabetic Igmu null mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sjogren’s syndrome. Proceedings of the National Academy of Sciences of the USA, 95, 7538- 7543.doi:10.1073/pnas.95.13.7538

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• TITLE: Clinical factors influencing the resting and stimulated salivary flow

  AUTHORS: Shigeo Yamachika, Ken Yamamoto, Yoshiaki Nomura, Hiroyuki Yamada, Ichiro Saito, Yoichi Nakagawa

  KEYWORDS: Xerostomia; Sialometry; Sialography; Labial Minor Salivary Gland Biopsy; Sjögren’s Syndrome

  JOURNAL NAME: Open Journal of Stomatology, Vol.2 No.2, June 12, 2012

  ABSTRACT: Objective: The objective of this study was to examine the clinical and immunological factors influ encing sialometry in xerostomia patients. Method: The association between sialometry and other clinical examinations were investigated in a cross-sectional study. A total of 179 dry mouth patients showing hyposalivation who underwent a clinical examination were enrolled in this study. Multiple regression analyses were employed to examine the relative con-tributions of clinical and immunological factors including age, gender, parotid sialography, labial Salivary gland biopsy, anti-Ro/SS-A antibodies, and anti-La/SS-B antibodies to the resting (RSF) or stimulated saliva flow rate (SSF). Results: An increase of the stage of sialography, the grade of a labial biopsy, and the presence of anti-La/SS-B antibody had a significant correlation with a decrease of sialometry. Results of the multiple regression analysis showed that age (standardized coefficient = -0.244), grade of lip biopsy (-0.189), and anti-SS-B antibody (-0.171), were significantly associated with the RSF. The stage of sialography (?0.423) and age (-0.169) were significantly related to the sialometry in the SSF according to a multiple regression analysis. Conclusion: The results of this study suggest that the measurement of RSF reflects the immunological factors and SSF reflects the damage to the parotid gland.