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Pfeffer, M.A., Burdmann, E.A., Chen, C.Y., Cooper, M.E., De Zeeuw, D., Eckardt, K.U., Feyzi, J.M., Ivanovich, P., Kewalramani, R., Levey, A.S., Lewis, E.F., McGill, J.B., McMurray, J.J., Parfrey, P., Parving, H.H., Remuzzi, G., Singh, A.K., Solomon, S.D., Toto, R., TREAT Investigators (2009) A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. New England Journal of Medicine, 361, 2019-2032. doi:10.1056/NEJMoa0907845

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• TITLE: The prevalence of renal anaemia in new dialysis patients before and after routine eGFR reporting: A single centre experience

  AUTHORS: Senyo K. Tagboto, Liz Cropper

  KEYWORDS: Anaemia; Estimated Glomerular Filtration Rate; Haemodialysis; Peritoneal Dialysis; MDRD Equation

  JOURNAL NAME: Open Journal of Internal Medicine, Vol.2 No.2, June 12, 2012

  ABSTRACT: Background: In March 2006, evidence-based guidelines for the management of chronic kidney disease (CKD) in adults in the UK were published including the recommendation that kidney function should be assessed by formula-based estimation of glomerular filtration rate (eGFR), using the 4-variable modification of diet in renal disease (MDRD) equation. The purpose of this study was to evaluate whether or not improved assessment of renal function by eGFR reporting followed by an intensive local education programme and local protocols affected the prevalence of renal anaemia at the time of starting dialysis for the first time. Methods: To do this, we collected data on haemoglobin levels in people starting renal replacement therapy (RRT) for the first time, during the 12 months immediately preceding eGFR reporting. We collected data for a further 12 months after eGFR was introduced; starting 6 months after the official date of introduction. Results: The proportion of people with Haemoglobin (Hb) levels ≥ 11 g/dl increased from 25.4% in the pre-eGFR era to 41.1% in the post eGFR era. In addition, average Hb levels were better in the post eGFR era (9.89 vs. 10.2 g/dl) although this did not reach statistically significance. In general, in the post eGFR era, people known to the renal services for less than 1 month prior to starting RRT had the worst Hb levels (8.7 g/dl). Hb levels were higher according to time of referral prior to RRT with peak Hb levels in people referred 6 - 9 months (11.5 g/dl) beforehand. Conclusions: It has been suggested that estimated GFR reporting may be associated with earlier recognition of kidney disease. This may have contributed to the increase in the proportion of people with optimal haemoglobin (≥11 g/dl) levels prior to starting renal replacement therapy. However a large number still start renal replacement therapy with severe anaemia. The increase in Hb levels in the post eGFR era could also result from better anaemia care which could be an effect of other guideline implementation.