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Okuda, K., Tai, H., Tanabe, K., Suzuki, H., Sato, T., Ka- wase, T., Saito, Y., Wolff, L.F. and Yoshie, H. (2005) Platelet-rich plasma combined with a porous hydroxyapa-tite graft for the treatment of intrabony periodontal de- fects in humans: A comparative controlled clinical study, Journal of Periodontology, 76, 890-898. doi:10.1902/jop.2005.76.6.890

has been cited by the following article:

• TITLE: The comparative effectiveness of granules or blocks of superporous hydroxyapatite for the treatment of intrabony periodontal defects

  AUTHORS: Yoshihide Shirai, Kazuhiro Okuda, Takehiko Kubota, Larry F. Wolff, Hiromasa Yoshie

  KEYWORDS: Superporous Hydroxyapatite; Granule; Block; Randomized Controlled Clinical Study

  JOURNAL NAME: Open Journal of Stomatology, Vol.2 No.2, June 12, 2012

  ABSTRACT: The aim of the present controlled clinical study was to compare the clinical response of grafting superporous hydroxyapatite (HAp) granules to superporous HAp blocks in the treatment of human intrabony periodontal defects. Twenty interproximal intrabony os-seous defects in 20 healthy, non-smoking subjects diagnosed with chronic periodontitis were included in this study. These twenty subjects were randomly assigned to either the HAp granule or the HAp block groups. Clinical and radiographic measurements were determined at baseline, 3, 6, 9 and 12-month post-surgical evaluation time periods. When compared to baseline, the 12-month results indicated both treatment procedures resulted in statistically significant favorable changes in probing depth (mean value: 3.5 mm versus 3.5 mm), clinical attachment level gain (3.2 mm versus 2.3 mm) and radiographic infrabony defect depth decrease (2.9 mm versus 2.5 mm) for HAp granule and HAp block grafting respectively. At 3- and 6-months, the granule group, when compared to the block group, exhibited a statistically significantly more favorable clinical response in clinical attachment level (4.1 mm versus 5.9 mm, p