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Schroeder, T., Zwelfer, V., Sagelsdorff, P., Friederich, U., Luthy J. and Schlatter, C. (1985) Ammoniation of aflatoxin-containing corn: Distribution, in vivo covalent deoxyribonucleic acid binding and mutagenicity. Journal of Agricultural Food Chemistry, 33, 311-316.

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• TITLE: Taxol as chemical detoxificant of aflatoxin produced by aspergillus flavus isolated from sunflower seed

  AUTHORS: Narasimhan Banu, Johnpaul Muthumary

  KEYWORDS: Aflatoxins; Taxol; Anticancerous Drug; Liver Cancer

  JOURNAL NAME: Health, Vol.2 No.7, July 23, 2010

  ABSTRACT: Aflatoxins are the potent toxic, mutagenic, heterogenic and carcinogenic metabolites produced by species of A. flavus and A. parasiticus. In the present study, an attempt has been made to prevent aflatoxin production using an anticancerous drug taxol. Taxol (Paclitaxel) is a well known drug for its anticancerous property mainly to treat breast and ovarian cancers. It was obtained from Taxus brevifolia and it was also obtained from the endophytic fungi present in Taxus brefivolia [1]. Therefore, this drug is specifically selected to screen its activity on the control of A. flavus and AFB1 production at various concentrations. Among the 6 concentrations used, 3 μg of taxol was found to be suitable to control the growth and AFB1 production. The content of AFB1 found at this concentration was 6 ppm by TLC and 6.3 ppm by HPTLC. The complete elimination of AFB1 might require higher concentrations of taxol.