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Yang, J., Yang, Y., Chen, J.M., Liu, W.Y., Wang, C.H. and Lin, B.C. (2008) Effect of hypothalamic supraoptic nucleus on acupuncture analgesia in the rat. Brain Research Bulletin, 75, 681-686. doi:10.1016/j.brainresbull.2007.11.004

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• TITLE: Oxytocin in rat nucleus raphe magnus influences pain modulation

  AUTHORS: Yanjuan Pan, Zhikui Yin, Jun Yang, Ying Zhao, Xiqing Yan, Peiyong Qiu, Daxin Wang

  KEYWORDS: Oxytocin; Oxytocin Receptor Antagonist; Nucleus Raphe Magnus; Pain Modulation

  JOURNAL NAME: World Journal of Neuroscience, Vol.2 No.2, May 29, 2012

  ABSTRACT: The main function of Nucleus raphe magnus (NRM) is mostly pain mediation. Our previous study has demonstrated that oxytocin (OXT) regulates antinociception through the central nervous system rather than the peripheral organs, and pain stimulation increases OXT concentration in the NRM. The experiment was designed to investigate OXT in the rat NRM effect on pain modulation. The results showed that 1) pain stimulation increased OXT concentration in NRM perfusion liquid; 2) Intra-NRM microinjection of OXT increased the pain threshold in a dose-dependent manner, whereas intra-NRM microinjection of OXT receptor antagonist, desGly-NH2, d(CH2)5[D-Tyr2, Thr-sup-4]OVT decreased the pain threshold; 3) NRM pre-treatment with OXT receptor antagonist completely attenuated the pain threshold increase induced by intra-NRM administration of OXT. The data suggested that OXT in NRM was involved in antinociception via OXT receptors.