TITLE:
Crystal structure of PqqB from Pseudomonas putida at 2.2 Å resolution
AUTHORS:
Moritz Metlitzky, Sandra Puehringer, Stuart J. Fisher
KEYWORDS:
PqqB; PQQ; Biosynthetic Pathway; X-Ray Crystallography
JOURNAL NAME:
Journal of Biophysical Chemistry,
Vol.3 No.2,
May
29,
2012
ABSTRACT: Pyrroloquinoline quinone (PQQ) is an important redox-active cofactor for many bacterial dehy-drogenases. It's biosynthetic pathway involves six or seven genes, one of which is pqqB. Former studies indicated that the protein encoded by pqqB, namely PqqB, functions as a PQQ transporter. Here we report the crystal structure of PqqB from Pseudomonas putida at 2.2 ? resolution together with functional studies to verify this theory.