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Fujitani, M., Cancino, G.I., Dugani, C.B., Weaver, I.C., Gauthier-Fisher, A., Paquin, A., Mak, T.W., Wojtowicz, M.J., Miller, F.D. and Kaplan, D.R. (2010) TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors. Current Biology, 20, 2058-2065. doi:10.1016/j.cub.2010.10.029

has been cited by the following article:

• TITLE: Hypertension effects on p73 expression in the rat circumventricular organs and cerebrospinal fluid

  AUTHORS: Emilia M. Carmona-Calero, Ibrahim González-Marrero, Manuela Castañeyra-Martin, Juan M. González-Toledo, Leandro Castañeyra-Ruiz, Héctor de Paz-Carmona, Agustín Castañeyra-Ruiz, Lidia Ruiz-Mayor, Agustín Castañeyra-Perdomo

  KEYWORDS: Circumventricular Organs; p73; CSF; Hypertensive Rats

  JOURNAL NAME: World Journal of Neuroscience, Vol.2 No.2, May 29, 2012

  ABSTRACT: It has been reported that spontaneously hypertensive rats (SHR) show ventricular dilation, changes in CSF proteins and variations in the circumventricular organs (CVO) such as: the subcommissural organ (SCO), the subfornical organ (SFO) and the area postrema (AP) which are located in the walls of the third and fourth ventricles. On the other hand, p73 proteins are present in cells of the central nervous system (CNS) such as circumventricular structures and the neuroepithelium which are altered in ventricular dilation. The purpose of the present work is to study the TAp73 isoform expression in the circumventricular organs (CVO) and their variations in ventricular dilatation and arterial hypertension. Brains and cerebrospinal fluid (CSF) from control Wistar-Kyoto rats (WKY) and SHR were used. The paraffin sections containing the CVO were immunohistochemically proc-essed with anti-TAp73 and by western blot, p73 bands in the CSF and circumventricular organ extract were also identified. The western blot study showed bands marked with p73 in the CSF and CVO, the p73 band expression was bigger in the SHR than in the WKY rats. We also found stronger markings in the SFO, SCO and AP of the hypertensive rats than in the WKY rats. It could be concluded that hypertension in the SHR produces altera-tions in the relationship between the p73 protein, circumventricular structures and CSF.