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Fetih, G., Habib, F., Katsumi, H., Okada, N., Fujita, T., Attia, M. and Yamamoto, A. (2006) Excellent absorption enhancing characteristics of NO donors for improving the intestinal absorption of poorly absorbable compound compared with conventional absorption enhancers. Drug Metabolism and Pharmacokinetics, 21, 222-229. doi:10.2133/dmpk.21.222

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• TITLE: Does pH of tyrode solution modify glucose and electrolyte jejunal absorption in rats?

  AUTHORS: Elizabeth Lage Borges, Marcelo de Pinho Viana

  KEYWORDS: Absorption; pH; Glucose; Sodium; Potassium; Jejunum

  JOURNAL NAME: Journal of Biophysical Chemistry, Vol.3 No.2, May 29, 2012

  ABSTRACT: Studies have shown that glucose is able to decrease the pH of the surface epithelium jejunal preparations when added in vitro and the existence of a high concentration of protons in the immediate area of the mucosa could be of considerable significance for absorption of electrolytes. The aim of this study is to assess whether the change in pH of Tyrode (solution used for perfusion of the jejunum) interferes with the absorption of glucose and electrolytes. Male Wistar rats weighing 200 to 220 g (n = 6) were utilized. Jejunal absorption of glucose and electrolytes was investigated in rats. A Tyrode solution containing twice glucose, sodium and potassium concentration (pH 7.0, 7.4, 8.0 and 8.5) was infused through the jejunal loops during 40 minutes. The glucose absorption was not significantly affected by Tyrode. However, there was significantly decrease in sodium absorption at pH 7.0 and 8.5 (41.13 ± 2.79 and 41.37 ± 1.71, respectively, P