TITLE:
A Patient with Intravenous Immunoglobulin-Responsive Lower Motor Neuron Syndrome
AUTHORS:
Takaomi Kessoku, Takashi Koide, Katsunori Akiyama, Sachiko Irie, Tadayuki Ishihara, Fumihito Yoshii
KEYWORDS:
Lower Motor Neuron Syndrome (LMNS); Multifocal Motor Neuropathy (MMN); Localized Proximal Muscle Weakness; Intravenous Immunoglobulin (IVIg); Anti-GM1 Ganglioside Antibody
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.3 No.3,
May
29,
2012
ABSTRACT: We report a 50-year-old woman who developed localized proximal muscle weakness, in addition to transient elevation of antibodies to GM-1 ganglioside, without multifocal conduction block. She was treated with intravenous immunoglobulin (IVIg) and steroid pulse therapy, which were effective for over 10 years. Her clinical course and laboratory tests were consistent with lower motor neuron syndrome (LMNS) with localized proximal muscle weakness. We suggest that some patients diagnosed as LMNS may remain responsive to IVIg or steroid pulse therapy for a long time.