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Ishii, Y., Ohta, T., Sasase, T., Morinaga, H., Hata, T., Miyajima, K., Katusda, Y., Masuyama, T., Shinohara, M., Kakutani, M. and Matsushita, M. (2010) A high-fat diet inhibits the progression of diabetes mellitus in type 2 diabetic rats. Nutrition Research, 30, 483-491.
doi:10.1016/j.nutres.2010.06.013
has been cited by the following article:
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TITLE:
Elevated glucagon-like peptide-1 on a high-fat diet feeding prevents the incidence of diabetes mellitus in Spontaneously Diabetic Torii Leprfa rats
AUTHORS:
Takahiro Hata, Takeshi Ohta, Yukihito Ishii, Tomohiko Sasase, Takayuki Yamaguchi, Yasuko Mera, Katsuhiro Miyajima, Gimpei Tanoue, Eimei Sato, Mutsuyoshi Matsushita
KEYWORDS:
Glucagon-Like Peptide-1; High Fat Diets; SDT Fatty Rats
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.2 No.2,
May
25,
2012
ABSTRACT: Nutritional regulation plays a critical role to reduce the incidence or progression of diabetes mellitus. In this study, we investigated the effects of a high-fat diet on Spontaneously Diabetic Torii Leprfa (SDT fatty) rats, a novel model for obese type 2 diabetes. The SDT fatty rats were divided into two dietary groups, which were fed a high-fat diet or a standard diet for 18 weeks, from 6 to 24 weeks of age. The calorie intake in the high-fat diet (HF) group was reduced after 10 weeks of age and the group inhibited an incidence of diabetes. Interestingly, the HF induced an increase of serum glucagon-like peptide-1 (GLP-1) levels in SDT fatty rats with refeeding. Fat tissue weights in the HF group increased, but the visceral fat/subcutaneous fat (V/S) ratio decreased. Moreover, histopathological observations revealed an improvement of the pancreatic abnormalities and fatty liver in the HF group. In conclusion, a preventive effect on diabetes in rats fed a high-fat diet has a relation with an increase in incretin hormone, and it might be advantageous for prevention of incidence or progression of diabetes to develop functional foods inducing an increase in incretin hormone.