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van der Veldt, A.A., Buist, M.R., van Baal, M.W., Comans, E.F., Hoekstra, O.S. and Molthoff, C.F. (2008) Clarifying the diagnosis of clinically suspected recurrence of cervical cancer: Impact of 18F-FDG PET. Journal of Nuclear Medicine, 49(12), 1936-1943.

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• TITLE: PET in uterine malignancies

  AUTHORS: Valeria Pirro, Andrea Skanjeti, Ettore Pelosi

  KEYWORDS: 18F-FDG PET/CT; Uterine Malignancies; Cervical Cancer; Endometrial Cancer;

  JOURNAL NAME: Health, Vol.2 No.7, July 23, 2010

  ABSTRACT: Positron Emission Tomography (PET) or integrated PET/Computed Tomography (PET/CT) with 18F-Fluoro-Deoxy-Glucose (18F-FDG) is a functional imaging modality, useful in the characterization of undetermined morphological findings, and in the staging/re-staging of a large number of malignancies. Although its use in uterine malignancies has been poorly investigated, in recent years the employment of this technique has constantly increased. In this review, we evaluate the role of PET (/CT) with 18FFDG in uterine malignancies (cervical and endometrial cancers as well as uterine sarcomas), underlying its advantages and discussing its limitations. Metabolic and anatomic information given by PET/CT with 18F-FDG could be useful in the evaluation of local and distant disease involvement at the staging, in the detection of disease recurrence, and in the evaluation of the response after chemotherapy and/or radio-therapy.