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Lopes, C.M., Rohacs, T., Czirjak, G., Balla, T., Enyedi, P. and Logothetis, D.E. (2005) PiP2-hydrolysis underlies agonist-induced inhibition and regulates voltage-gating of 2-P domain K+ channels. The Journal of Physiology, 564, 117-129. doi:10.1113/jphysiol.2004.081935

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• TITLE: Smart fats, healthy brain and function of lipid-sensing NMDA receptors

  AUTHORS: Anna Kloda, Boris Martinac

  KEYWORDS: NMDA Receptors; Lipid Bilayer; Membrane Phospholipids; Fatty Acids; Synaptic Plasticity; Dementia, Alzheimer’s Disease

  JOURNAL NAME: Advances in Biological Chemistry, Vol.2 No.2, May 10, 2012

  ABSTRACT: NMDA receptor channels play a significant role in learning and memory and their dysfunction can cause neuronal cell death leading to dementia. Research had shown that lipids change the risk for dementia, especially some omega-3 lipids appear to lower Alz-heimer’s risk, yet only limited research exists on the modulation of NMDA receptor channels by lipids. Here we review recent literature concerning molecular determinants that influence the NMDA receptor channel gating via membrane lipids and fatty acids with profound significance for understanding how altered NMDA signalling leads to neuronal cell death linked to age-related dementia’s. Future discovery of lipid-like modulators of NMDA receptor function offer the potential for the development of new bioceu-ticals and affordable nutritional supplements to combat neuronal degeneration as well as to promote well being and healthy aging.