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J. B. Jones and J. M. Young, “Carcinogenicity of Lactones III: The Reactions of Unsaturated 4-Lactones with l-Cysteine,” Journal of Medicinal Chemistry, Vol. 11, No. 6, 1968, pp. 1176-1182. doi:10.1021/jm00312a017

has been cited by the following article:

• TITLE: A Novel Antibacterial Dental Resin Composite

  AUTHORS: Yiming Weng, Voon J. Chong, Leah Howard, Ruijie Huang, Richard L. Gregory, Dong Xie

  KEYWORDS: Furanone Derivative; Antibacterial; Resin Composite; CS; S. mutans Viability

  JOURNAL NAME: Journal of Biomaterials and Nanobiotechnology, Vol.3 No.2, April 28, 2012

  ABSTRACT: This study reports the synthesis and evaluation of a novel furanone-containing antibacterial resin composite. Compres-sive strength (CS) and S. mutans viability were used to evaluate the mechanical strength and antibacterial activity of the composites. With 5% to 30% addition of the furanone derivative, the composite showed no change in CS but a significant antibacterial activity with a 16% - 68% reduction in the S. mutans viability. Further, the antibacterial activity of the modified composite was not affected by human saliva. The aging study implies that the modified composite may have a long-lasting antibacterial function. Within the limitations of this study, it appears that this experimental resin composite may potentially be developed into a clinically attractive dental restorative due to its high mechanical strength and antibacterial function.