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E. Lattmann, S. Dunn, S. Niamsanit and N. Sattayasai, “Synthesis and Antibacterial Activities of 5-Hydroxy-4- Amino-2(5H)-Furanones,” Bioorganic & Medicinal Chemistry Letters, Vol. 15, No. 4, 2005, pp. 919-921. doi:10.1016/j.bmcl.2004.12.051

has been cited by the following article:

• TITLE: A Novel Antibacterial Dental Resin Composite

  AUTHORS: Yiming Weng, Voon J. Chong, Leah Howard, Ruijie Huang, Richard L. Gregory, Dong Xie

  KEYWORDS: Furanone Derivative; Antibacterial; Resin Composite; CS; S. mutans Viability

  JOURNAL NAME: Journal of Biomaterials and Nanobiotechnology, Vol.3 No.2, April 28, 2012

  ABSTRACT: This study reports the synthesis and evaluation of a novel furanone-containing antibacterial resin composite. Compres-sive strength (CS) and S. mutans viability were used to evaluate the mechanical strength and antibacterial activity of the composites. With 5% to 30% addition of the furanone derivative, the composite showed no change in CS but a significant antibacterial activity with a 16% - 68% reduction in the S. mutans viability. Further, the antibacterial activity of the modified composite was not affected by human saliva. The aging study implies that the modified composite may have a long-lasting antibacterial function. Within the limitations of this study, it appears that this experimental resin composite may potentially be developed into a clinically attractive dental restorative due to its high mechanical strength and antibacterial function.