TITLE:
The Value of NT-ProBNP in Combination with WBC, PLT, and D-Dimer for Assessing the Severity of Heart Failure Patients
AUTHORS:
Jun He, Qianping Xu, Chunjiao Nong, Xiangbing Zou, Yonghao Chen
KEYWORDS:
NT-ProBNP, WBC, PLT, D-Dimer, Heart Failure, Severity Evaluation
JOURNAL NAME:
Natural Science,
Vol.18 No.11,
November
11,
2026
ABSTRACT: Objective: To explore the value of combined detection of N-terminal pro-B-type natriuretic peptide (NT-ProBNP), white blood cell count (WBC), platelet count (PLT) and D-dimer (D-Dimer) in evaluating the severity of patients with heart failure. Methods: A retrospective study was conducted. A total of 198 patients diagnosed with heart failure who received treatment in Guangxi-ASEAN Economic and Technological Development Zone People’s Hospital (Nanning Tenth People’s Hospital) from January 2024 to June 2025 were enrolled. According to the New York Heart Association (NYHA) cardiac functional classification, patients were divided into NYHA class I-II group (59 cases) and NYHA class III-IV group (139 cases). The differences in levels of NT-ProBNP, WBC, PLT, D-Dimer and other indicators between the two groups were compared. Multivariate logistic regression analysis was applied to identify influencing factors for increased severity of heart failure. Receiver operating characteristic (ROC) curves were plotted to analyze the predictive value of single-indicator detection and combined-indicator detection for heart failure severity. Results: The NT-ProBNP level in patients of NYHA class III-IV group was significantly higher than that in NYHA class I-II group, with statistically significant difference (P