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Preische, O., Schultz, S.A., Apel, A., Kuhle, J., Kaeser, S.A., Barro, C., et al. (2019) Serum Neurofilament Dynamics Predicts Neurodegeneration and Clinical Progression in Presymptomatic Alzheimer’s Disease. Nature Medicine, 25, 277-283.
https://doi.org/10.1038/s41591-018-0304-3

has been cited by the following article:

• TITLE: Role of Aqueous Humor Light Chain Proteins in Glaucomatous Neurodegeneration

  AUTHORS: Tian Tian, Guojin Zuo, Qi Wang, Yanni Zhu

  KEYWORDS: Neurofilament Light Chain, Glaucoma, Aqueous Humor, Neurodegeneration

  JOURNAL NAME: Yangtze Medicine, Vol.10 No.4, November 9, 2026

  ABSTRACT: Objectives: This paper aims to evaluate the predictive clinical role of Aqueous Humor Neurofilament light chain (NfL) Proteins in human aqueous humor (AH). Methods: In this single-center study, 37 patients were enrolled, including 21 glaucoma patients and 16 non-glaucoma patients. AH samples were collected during planned ophthalmic surgery. AH NfL was quantified using the Single Molecule Array (Simoa)® NF-light assay (Quanterix). Clinical information was obtained by reviewing the medical records. Between-group comparisons were performed using the Mann-Whitney U test for continuous variables and Fisher’s exact test for categorical variables. Results: In a model controlling for age and body mass index (BMI), NfL was significantly elevated in AH from glaucoma patients (519 ± 671 pg/mL) compared to AH from patients without glaucoma (5.6 ± 2.3 pg/ml, P Conclusions: AH NfL is significantly elevated in glaucoma patients. Our findings suggest that AH NfL may have clinical utility as a marker of glaucomatous neurodegeneration. Larger, multicenter studies are warranted to confirm these findings.