TITLE:
Research Progress on Step-Wise Therapy of Urosepsis
AUTHORS:
Yuxing Xie, Shaoping Cheng, Zhigang Huang
KEYWORDS:
Urosepsis, Step-Wise Therapy, Antimicrobial Therapy, Supportive Care, Surgical Source Control, Risk Stratification
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.14 No.11,
November
9,
2026
ABSTRACT: Urosepsis is a life-threatening condition: organ dysfunction arises when the host response to a urinary-tract infection becomes dysregulated. It still causes substantial illness and death worldwide, particularly in older patients and those with multiple comorbidities. Conventional empirical antibiotics and supportive care run into clear practical limits in complicated cases and as antimicrobial resistance rises. Step-wise therapy has gradually become the main management approach for urosepsis. It brings together anti-infective treatment, comprehensive organ support and timely surgical source control, and adjusts intervention intensity dynamically according to disease severity, physiological status and real-time clinical response. This review covers the etiology, immunopathogenesis, current diagnostic criteria and risk stratification of urosepsis. It then discusses, component by component, therapeutic indications, practical efficacy metrics and targeted complication-prevention strategies under step-wise management. The aim is to consolidate existing clinical evidence, give front-line urologists and intensive-care clinicians a standardized decision-making reference, and ultimately improve long-term survival and quality of life for affected patients.