TITLE:
Factors Associated with the Severity of Perinatal Asphyxia Complicated by Hypoxic-Ischemic Encephalopathy in the Neonatal Unit of University Hospital Center Sourô SANOU of Bobo-Dioulasso
AUTHORS:
Bintou Sanogo, Latifatou Tiendrébéogo, Fatimata Sahoura Nacro, Saga Alain Ouermi, Ahmed Cheick Ouattara, Nikiema Germain, Fatimata Zongo, Souleymane Konaté, Mariéta Sidanoma Tinto, Nakoulma Mahamadi, Ouoba Souanguimpari René, Ouattara Ad Bafa Ibrahim, Makoura Barro, Senkaye-Lagom Aimée Kissou
KEYWORDS:
Perinatal Asphyxia, Anoxic-Ischemic Encephalopathy, Prognosis, CHU-SS, Burkina Faso
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.16 No.6,
November
5,
2026
ABSTRACT: Introduction: Perinatal asphyxia (PNA) is a major cause of neonatal morbidity and mortality. The objective of this study was to examine the perinatal characteristics and short-term clinical aspects of PNA and to determine factors associated with the severity of hypoxic-ischemic encephalopathy (HIE) in the neonatal unit of University Hospital Center Sourô Sanou, Bobo-Dioulasso. Methods: This was a cross-sectional study with descriptive and analytical objectives, focusing on eutrophic, full-term infants hospitalized for perinatal asphyxia complicated by hypoxic-ischemic encephalopathy (Apgar score Results: The frequency of perinatal asphyxia complicated by hypoxic-ischemic encephalopathy was 20.23%. Stages I, II, and III of AIE accounted for 45.17%, 42.82%, and 12.01%, respectively. The average length of hospital stay was 5 days, and in-hospital mortality rate was 30.55%. Circular umbilical cord (OR = 2.81; CI = [1.29 - 6.12]; p = 0.010), maternal-fetal infection (OR = 3.29; CI = [1.22 - 8.87]; p = 0.019), Apgar score > 7 at fifth minute of life (OR = 0.47; CI = [0.28 - 0.78]; p = 0.004), and a resuscitation duration ≤ 10 minutes (OR = 0.25; CI = [0.11 - 0.55]; p = 0.001) were the main factors associated with the severity of hypoxic-ischemic encephalopathy. Conclusion: Improved prenatal care and neonatal resuscitation techniques could help reduce morbidity and mortality associated with perinatal asphyxia complicated by hypoxic-ischemic encephalopathy.