TITLE:
Malignant Phyllodes Tumor of the Breast. Case Report and Literature Review
AUTHORS:
Carlos Hernández Brito, Arturo Hernández Reyes, Miguel Ángel Lara Salazar, Omar Josué Herrera López, Luis Eduardo Méndez Turrubiates, Yedid Domínguez Suárez, Luis Ángel Amezcua Toledo, Víctor Domínguez Osorio, Brenda Paola Sáenz Dávila, Pedro Arredondo Ruiz, Arsenio Torres Delgado, Óscar Mauricio López Gil
KEYWORDS:
Phyllodes Tumor, Malignant Phyllodes Tumor, Breast Sarcoma, Fibroepithelial Lesion with Increased Stromal Cellularity, Fibroadenoma
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.15 No.4,
October
27,
2026
ABSTRACT: Background: Phyllodes tumor accounts for less than 1% of all primary breast tumors and only 8% to 20% of cases are malignant; due to their rarity most treatments are based on retrospective studies. Aim: Describing the current recommendations for the diagnostic approach and treatment of these neoplasms. Case Presentation: A 59-year-old woman with a progressively and rapidly growing phyllodes tumor of the breast treated by total mastectomy classified as malignant on the final histopathological report. Conclusion: Current recommendations for the treatment of phyllodes tumor are not standardized. The treatment of choice is surgical resection either by lumpectomy or total mastectomy achieving a negative resection margin. With regard to adjuvant therapy, radiotherapy is most beneficial for malignant subtype.