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Najmi, A., Javed, S.A., Al Bratty, M. and Alhazmi, H.A. (2022) Modern Approaches in the Discovery and Development of Plant-Based Natural Products and Their Analogues as Potential Therapeutic Agents. Molecules, 27, Article 349.
https://doi.org/10.3390/molecules27020349

has been cited by the following article:

• TITLE: Phytochemical Profiling and Bioactivity Assessment of Alternanthera philoxeroides and in Silico Evaluation of Dendryphiellin I Isolated from Its Endophytic Fungi

  AUTHORS: Abdur Rahman, Md. Saiful Islam, Mst. Nadira Begum, Rabita Zinnurine, Tawhida Akter, Kutub Uddin Ahamed, Satyajit Roy Rony, Choudhury Mahmood Hasan, Md. Hossain Sohrab

  KEYWORDS: Alternanthera philoxeroides, Phytochemical, FTIR, NMR, Antioxidant Activity, Antimicrobial, Molecular Docking

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.17 No.10, October 23, 2026

  ABSTRACT: Alternanthera philoxeroides (Mart.) Griseb., locally known as Malancha shak, is a medicinally important leafy vegetable found in Bangladesh. This study investigated the phytochemical profile and biological activities of the methanolic extract, as well as the isolation and characterization of an endophytic fungal metabolite. FTIR and NMR analyses demonstrated the presence of varied functional groups and secondary metabolites. The extract showed moderate DPPH radical-scavenging activity, with an IC50 value of 127.48 ± 0.53 µg/mL, and antibacterial activity against Bacillus cereus (11.5 mm), Pseudomonas aeruginosa (12 mm), Staphylococcus aureus (9 mm), and Escherichia coli (9 mm), whereas it exhibited no activity against Salmonella typhi and the tested fungi. The corresponding endophytic fungus was identified as Curvularia sp., from which Dendryphiellin I was isolated and characterized. Molecular docking and ADMET analyses provided preliminary computational evidence of potential biological activity and drug-like properties of Dendryphiellin I.