TITLE:
Multi-Signaling Pathway Cross-Regulatory Network of Fortified Qifang Stomachache-Relieving Granules against Precancerous Lesions of Gastric Cancer: A Comprehensive Review
AUTHORS:
En Zhao, Ting Wang, Qiuting Luan, Liang Chang
KEYWORDS:
Fortified Qifang Stomachache-Relieving Granules, Precancerous Lesions of Gastric Cancer, Multi-Signaling Pathways, Cross-Regulatory Network
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.14 No.10,
October
23,
2026
ABSTRACT: Precancerous Lesions of Gastric Cancer (PLGC) represent a crucial reversible node in the malignant progression from gastritis to gastric cancer. Effectively blocking and reversing PLGC is the core strategy for reducing the incidence of gastric cancer. Fortified Qifang Stomachache-relieving Granules (FQSG) have shown significant clinical efficacy in the clinical prevention and treatment of PLGC. As an effective traditional Chinese medicine compound for the clinical treatment of chronic atrophic gastritis, FQSG could strengthen the spleen, replenish qi, clear heat and resolve dampness, as well as promote blood circulation and remove blood stasis. Clinical observations suggest that it could improve the pathological damage of the gastric mucosa and reverse intestinal metaplasia and dysplasia in PLGC. Compared with single-target drugs, this compound with its characteristics of multiple components, multiple targets, and multiple pathways, could interfere with the inflammation-cancer transformation process of PLGC through a cross-regulatory network of multiple signaling pathways. This paper systematically reviews the relevant research progress in recent years, focusing on core pathways such as Wnt/β-catenin, PI3K/Akt, NF-κB, MAPK, and TGF-β. It emphasizes the regulatory mechanisms of cell proliferation, apoptosis, inflammation, and epithelial mesenchymal transition mediated by each pathway, analyzes the network rules of cross-talk and synergistic anti-cancer effects among pathways to clarify the scientific connotation of FQSG in anti-PLGC and provide theoretical support for its precise clinical application and subsequent new drug research and development.