TITLE:
Comparison of Laparoscopic Approach and Laparotomy in Patients with Endometrioid Adenocarcinoma
AUTHORS:
Eralp Ceviker, Gamze Yetim Erdem, Mesut Polat, Mehmet Kücükbas, Mehmet Baki Senturk, Oğuz Devrim Yardimci, Ates Karateke, Emel Kurtoglu Ozdes
KEYWORDS:
Endometrial Cancer, Endometrioid Adenocarcinoma, Hysterectomy, Total Laparoscopic Hysterectomy, Total Abdominal Hysterectomy
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.14 No.10,
October
19,
2026
ABSTRACT: Objective: This study aimed to compare the laparoscopic approach with laparotomy for patients with endometrioid adenocarcinoma. Methods: Data from 206 patients who underwent laparoscopic and laparotomy approaches for endometrial adenocarcinoma between March 2016 and November 2019 were reviewed retrospectively from hospital records. The following were evaluated and compared: demographics, comorbidities, pre- and postoperative CA-125 levels, disease stage, tumor diameter, histological grade, depth of myometrial invasion, number of lymph nodes retrieved, postoperative hospital stay, and postoperative treatments (chemotherapy, radiotherapy, and brachytherapy). Results: Among stage IA patients, 41.07% underwent total abdominal hysterectomy (TAH) and 58.93% underwent total laparoscopic hysterectomy (TLH). Among stage 1B patients, 58.82% underwent TAH and 41.18% underwent TLH. Among stage II patients, 76.47% underwent TAH and 23.53% underwent TLH. Among stage III patients, 85.29% underwent TAH and 14.71% underwent TLH. All stage IV patients underwent TAH. No statistically significant differences were observed between the two groups for staging and grading, as well as age, gravidity, parity, tumor grade, tumor diameter, number of paraaortic lymph nodes, pre- and postoperative CA-125 levels and cancer recurrence rates. On the other hand, mean number of pelvic lymph nodes retrieved was 23.67 in the laparotomy group and 27.72 in the laparoscopic group (p = 0.02), and the length of hospital stay was 2 - 9 (mean 3.65) days for TAH patients and 1 - 7 (mean 1.98) days for TLH patients (p = 0.05). Conclusion: Laparoscopic surgery for endometrial cancer is associated with lower morbidity than laparotomy and characterized by a shorter postoperative hospital stay and reduced analgesic requirements.