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Bonazzetti, C., Morena, V., Giacomelli, A., Oreni, L., Casalini, G., Galimberti, L.R., et al. (2020) Unexpectedly High Frequency of Enterococcal Bloodstream Infections in Coronavirus Disease 2019 Patients Admitted to an Italian ICU: An Observational Study. Critical Care Medicine, 49, e31-e40.
https://doi.org/10.1097/ccm.0000000000004748

has been cited by the following article:

• TITLE: Bloodstream Infections in Patients with COVID-19 Admitted to Intensive Care Units in Europe: A Literature Review and Meta-Analysis

  AUTHORS: António Martins, David Reid

  KEYWORDS: Bloodstream Infections, COVID-19, Intensive Care Unit

  JOURNAL NAME: Advances in Infectious Diseases, Vol.16 No.3, September 30, 2026

  ABSTRACT: Patients with COVID-19 admitted to intensive care unit (ICU) have an increased risk of bloodstream infections (BSI), compared to patients without COVID-19. To date, no literature review and meta-analysis of the incidence rate of BSI in these patients is available. A literature review was performed based on a systematic search from January 2020 to December 2023. Eligible studies had to address the incidence rate of BSI in adult patients with COVID-19 admitted to ICU within Europe. Data on incidence and mortality rates was collected. A meta-analysis was conducted to estimate the pooled incidence rate. Twelve studies met eligibility criteria. The incidence rate of BSI in patients with COVID-19 admitted to ICU varied between 6.4 and 92/1000 patient-days with a mortality rate between 25% and 54%. The pooled incidence rate was 29.5/1000 patient-days (95% CI 12.1 - 71.6) with substantial heterogeneity observed. Compared to non-COVID-19 patients admitted to ICU during the pandemic, the incidence rate of BSI was higher. According to this literature review and meta-analysis, the incidence rate of BSI in patients with COVID-19 admitted to ICU is two-fold higher. Clinical teams taking care of these patients should adapt BSI prevention protocols and antimicrobial treatments.