TITLE:
Clinical Profile of Female Hyperprolactinemia at the Level of the Gynecology/Obstetrics Department of the Mali Hospital
AUTHORS:
Mamadou Bakary Coulibaly, Alou Diarra, Sow Djénéba Sylla, Alassane Traore, Seydou Mariko, Bah Traore, Modibo Bouran Diallo, Abdramane Togo, Issa Ongoïba, Absatou Traore, Mody Abdoulaye Camara, Soungalo Diakite, Bakary Traore
KEYWORDS:
Female Hyper Prolactinemia, Fertility Disorder, Conception and Pregnancy Outcomes, Mali Hospital
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.16 No.9,
September
30,
2026
ABSTRACT: Introduction: Hyperprolactinemia is an excessive supraphysiological secretion of prolactin. The aim of this work was to evaluate the clinical and therapeutic profile of patients, and to assess its impact on fertility. Patients and method: This is a prospective longitudinal study from January 1, 2019 to June 30, 2022 on all patients of childbearing age seen monthly in consultation. Included were any patients in whom the prolactin dosage was greater than 25 ng/ml. Results: We collected 43 cases of hyperprolactinemia out of a total of 5187 new consultations or 0.82%. The mean age of the patients was 28.33 years with extremes between 17 and 44 years old. The desire to become pregnant was the most frequent reason (79.06%). Primary infertility concerned 65.1% of patients. The main clinical signs were: cycle disorders 41.8%, followed by amenorrhea/galactorrhea association 46.5%; neurological signs (nervousness, headache, visual disturbances) 18.6%. The mean level of prolactinemia was between 25 and 100 ng/mml in 53.5% of cases. Brain CT was requested for cases of prolactinemia greater than 200 ng/mml and 23.25% of patients had a prolactin adenoma. Ovarian reserve was satisfactory in 60.46%. Treatment was medicated in 81.4% with cabergoline. Clinical improvement was obtained in 23.3% of patients after one month, 37.2% after 3 months. Pregnancy occurred in 39.53% of patients. All pregnancies reached term except for one case of spontaneous abortion. We noted a statistically significant relationship between the rate of prolactinemia and clinical signs (P Conclusion: Hyperprolactinemia is a common cause of disorders of the hypothalamic-pituitary axis, thus causing female infertility. But drug treatment remains effective.