TITLE:
Major Sickle Cell Disease and Pregnancy: Epidemiology and Prognosis, Based on 65 Cases at Bogodogo University Teaching Hospital (CHU-B)
AUTHORS:
Hamado Sawadogo, Adjaratou Fabienne Sanou, Adama Ouattara, Charlemagne Marie Ouédraogo
KEYWORDS:
Sickle Cell Disease, Pregnancy, Prognostic, Burkina Faso
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.16 No.9,
September
29,
2026
ABSTRACT: Goal: The goal of this study was to study the epidemiological, clinical, therapeutic and prognostic aspects of sickle cell disease and pregnancy at Bogodogo University Teaching Hospital (CHU-B) in Burkina Faso. Materials and Methods: This was a cross-sectional retrospective study at the Bogodogo University Teaching Hospital (CHU-B) in Burkina Faso over a period of 18 months, from March 15, 2018, to September 15, 2019, among pregnant women who have major sickle cell disease and pregnancy and consulting in the obstetrics and gynecology department of CHU-B. The data were collected mainly from patients’ medical records using a standardized data collection form. The parameters analyzed were the gynecological obstetrical antecedents related to sickle cell disease, physical examination findings, maternal, fetal complications etc. Results: Sixty-five (65) patients were included in the study. The average age of women was (25.6 ± 5.7 years old). The majority of patients were paucigestes 69.2% and primipara 55.4%. Sickle cell disease was accidentally discovered in 24.6% of our patients during pregnancy and 21.5% of women have a history of transfusion. The complications of sickle cell disease in the pregnancy were dominated by vaso-occlusive crises which involved seventy-two point three percent (72.3%). One of the chronic complications found is retinopathy 6.1%. Postpartum complications related to sickle cell disease were anemia 38.4%. The fetal complications were: 4.6% growth retardation, intra uterine fetal death 9.2%, neonatal death 6.1%, abortion 1.5%. The hemoglobin phenotype was 89.2% HbSC and 10.8% HbSS. Blood transfusion of RGC was performed in 32.3% of patients. Type of delivery: Cesarean section 60.4%, vaginal delivery 39.6%. The case-fatality proportion was 9.2%. Conclusion: The association of major sickle cell disease and pregnancy is responsible for significant maternal and fetal morbidity and high case-fatality proportion. Regular medical monitoring and management are necessary.