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G. Mancia, S. Laurent, E. Agabiti-Rosei, E. Ambrosioni, M. Burnier, M. J. Caulfield, R. Cifkova, D. Clément, A. Coca, A. Dominiczak, S. Erdine, R. Fagard, C. Farsang, G. Grassi, H. Haller, A. Heagerty, S. E. Kjeldsen, W. Kiowski, J. M. Mallion, A. Manolis, K. Narkiewicz, P. Nilsson, M. H. Olsen, K. H. Rahn, J. Redon, J. Rodicio, L. Ruilope, R. E. Schmieder, H. A. Struijker-Boudier, P. A. van Zwieten, M. Viigimaa and A. Zanchetti, “Reappraisal of European Guidelines on Hypertension Management: An European So

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• TITLE: Effect of Antihypertensive Drug Therapy on the Blood Pressure Control among Hypertensive Patients Attending Campus’ Teaching Hospital of Lome, Togo, West Africa

  AUTHORS: Yao Potchoo, Edem Goe-Akue, Findibe Damorou, Barima Massoka, Datouda Redah, Innocent P. Guissou

  KEYWORDS: Antihypertensive Drugs; Ambulatory Patients; Hospitalized Patients; Blood Pressure Control; Prescription; Monotherapy; Bitherapy; Tritherapy; Quadritherapy; CHU-Campus; Togo; West Africa

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.3 No.2, April 25, 2012

  ABSTRACT: High blood pressure (HBP) is a health problem world—wide. In Togo, that affection constitutes a more and more pre-occupying cause of morbidity and mortality. This study is a prospective one which intended to identify the antihypertensive regimens prescribed and evaluate their effect on patients’ blood pressure (BP) control. Out of the 204 patients enrolled (mean: 55.01 ± 12.55 years; sex ratio: 1.3), 112/176 placed on antihypertensive therapy have controlled their BP (38.39% outpatients vs 61.61% inpatients). Related to the sex factor, we didn’t observe any significant difference in the BP control. Whereas, the mean median value of BP reduction of outpatients (30.00/15.00 mmHg) (p = 0.001) was half lower than that of inpatients (60.00/30.00 mmHg (p = 0.004)). Thirty five outpatients (81.40%) vs 64 inpatients (92.75%) were placed on combination therapy. The bitherapy was prescribed to 23 outpatients (53.49%) against 27 inpatients (39.13%) while the quadritherapy and more than 4 drugs combination were prescribed exclusively to inpatients (20.29%, n = 14). That quadritherapy induced a significant mean reduction of inpatients’ SBP compared to monotherapy (p = 0.043) and to bitherapy (p = 0.004). The favorite combinations were D + CCA, D + ACEI, D + CCA + ACEI and D + CCA + ACEI + CAAD of which the quadruple therapy showed a significant inpatients’ DBP control (p = 0.015) compared to D + CCA combination. The combinations including at least one diuretic induced a significant difference between outpatients (median value: 30.000/10.000 mmHg) (p