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J. Pool, W. C. Cushman, R. K. Saini, C. E. Nwachuku and J. P. Battikha, “Use of the Factorial Design and Quadratic Response Surface Models to Evaluate the Fosinopril and Hydrochlorothiazide Combination Therapy in Hypertension,” American Journal of Hypertension, Vol. 10, No. 1, 1997, pp. 117-123. doi:10.1016/S0895-7061(96)00323-8

has been cited by the following article:

• TITLE: Effect of Antihypertensive Drug Therapy on the Blood Pressure Control among Hypertensive Patients Attending Campus’ Teaching Hospital of Lome, Togo, West Africa

  AUTHORS: Yao Potchoo, Edem Goe-Akue, Findibe Damorou, Barima Massoka, Datouda Redah, Innocent P. Guissou

  KEYWORDS: Antihypertensive Drugs; Ambulatory Patients; Hospitalized Patients; Blood Pressure Control; Prescription; Monotherapy; Bitherapy; Tritherapy; Quadritherapy; CHU-Campus; Togo; West Africa

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.3 No.2, April 25, 2012

  ABSTRACT: High blood pressure (HBP) is a health problem world—wide. In Togo, that affection constitutes a more and more pre-occupying cause of morbidity and mortality. This study is a prospective one which intended to identify the antihypertensive regimens prescribed and evaluate their effect on patients’ blood pressure (BP) control. Out of the 204 patients enrolled (mean: 55.01 ± 12.55 years; sex ratio: 1.3), 112/176 placed on antihypertensive therapy have controlled their BP (38.39% outpatients vs 61.61% inpatients). Related to the sex factor, we didn’t observe any significant difference in the BP control. Whereas, the mean median value of BP reduction of outpatients (30.00/15.00 mmHg) (p = 0.001) was half lower than that of inpatients (60.00/30.00 mmHg (p = 0.004)). Thirty five outpatients (81.40%) vs 64 inpatients (92.75%) were placed on combination therapy. The bitherapy was prescribed to 23 outpatients (53.49%) against 27 inpatients (39.13%) while the quadritherapy and more than 4 drugs combination were prescribed exclusively to inpatients (20.29%, n = 14). That quadritherapy induced a significant mean reduction of inpatients’ SBP compared to monotherapy (p = 0.043) and to bitherapy (p = 0.004). The favorite combinations were D + CCA, D + ACEI, D + CCA + ACEI and D + CCA + ACEI + CAAD of which the quadruple therapy showed a significant inpatients’ DBP control (p = 0.015) compared to D + CCA combination. The combinations including at least one diuretic induced a significant difference between outpatients (median value: 30.000/10.000 mmHg) (p