TITLE:
The Predictive Value of the Preoperative Fibrinogen-to-Prealbumin Ratio for Overall Survival in Patients with Resectable Stage I - III Colorectal Cancer
AUTHORS:
Tianlong Zhou, Zilong Zhang
KEYWORDS:
Colorectal Cancer, Fibrinogen, Prealbumin, Fibrinogen-to-Prealbumin Ratio, Overall Survival, Prognosis
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.14 No.9,
September
21,
2026
ABSTRACT: Objective: This paper aims to evaluate the prognostic value of the preoperative fibrinogen-to-prealbumin ratio (FPR) for 5-year overall survival (OS) in patients with resectable stage I - III colorectal cancer (CRC). Methods: This retrospective cohort included 159 patients with stage I - III CRC who underwent R0 resection at Jingzhou Central Hospital between January and December 2020. Clinicopathological characteristics, preoperative laboratory indices, and follow-up data were collected. X-tile 3.6.1 was used to determine optimal cut-off values. Receiver operating characteristic (ROC) analysis, Kaplan-Meier survival analysis with the log-rank test, and univariable and multivariable Cox proportional hazards models were performed. Results: The optimal FPR cut-off for 5-year OS was 30.7342, yielding 119 patients in the low-FPR group and 40 in the high-FPR group. Patients with high FPR were older and more frequently had stage III disease, elevated CA19-9, and perineural invasion (all P χ2 = 48.564, P χ2 = 18.256, P Conclusion: Preoperative FPR is associated with long-term survival after curative resection for stage I - III CRC and may serve as a simple adjunct for postoperative risk stratification, particularly in stage III disease.