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Summers, Y.J., Heyworth, C.M., de Wynter, E.A., Hart, C.A., Chang, J., et al. (2004) AC133+ G0 cells from cord blood show a high incidence of long-term culture-initiating cells and a capacity for more than 100 million-fold amplification of colony-forming cells in vitro. Stem Cells, 22, 704-715. doi:10.1634/stemcells.22-5-704

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• TITLE: The CD133/1+ cell subset from human subcutaneous adult fat retains hemogenic potential

  AUTHORS: Camila Santos de Moraes, Paulo Roberto Albuquerque Leal, Daniel Fabiano Ferreira, Fernando Serra, Eliana Abdelhay, Claudia Sondermann Freitas

  KEYWORDS: Adipose Tissue-Derived Stem Cells; CD133; Hematogenesis; Hemangioblast; Pericyte

  JOURNAL NAME: Stem Cell Discovery, Vol.2 No.2, April 25, 2012

  ABSTRACT: Research has shown that cells from adult fat tissue can effect long-term blood reconstitution. Fat-derived multipotentiality was ascribed to CD34+ perivascular populations from its prominent microvasculature, that represent mostly non-hemogenic, mesenchymal cells, although this tissue contains a CD34+45+ subset committed to a hemogenic fate. Here, in order to analyze cell subsets presenting hemogenic capabilities within fat, CD133/1+ and pericytes, the latter defined by CD140b (PDGFRb, Platelet-Derived Growth Factor Receptor Beta) expression, were immunomagnetically selected from stromal-vascular fractions (SVF). In Vitro Colony Forming Unit (CFU) assays were negative for CD140b+ pericytes and positive for CD133/1+ cells when a prolonged CFU assay was performed, revealing fat as another store of primitive progenitors that retain hemogenic potential.