TITLE:
Kinetic Validation by MATLAB Simulation of the Ni(III)-HmP Decomposition Step in Nickel-Mediated Histamine Oxidation: Comparison with Thin-Layer Voltammetry
AUTHORS:
Koita Demo, Mendy Paul, Diedhiou Moussa Bagha, Sambou Vincent, Diaw Mahy, Sock Oumar
KEYWORDS:
Histamine, Thin-Layer Voltammetry, Electrocatalytic Sensors, Kinetic Simulation, MATLAB
JOURNAL NAME:
American Journal of Analytical Chemistry,
Vol.17 No.9,
September
18,
2026
ABSTRACT: The complexation constant (K) governing the interaction between histamine (Hm) and nickel ions is a critical parameter for developing electrochemical biosensors for food safety monitoring. For the equilibrium
Ni
(
OH
)
2
+Hm⇌HmNi(
II
)+2
OH
−
, a mass-balance estimate based on our earlier work
K ≈ 2.5×
10
6
[1] confirms a strong Hm-Ni(II) affinity; this value is not re-derived here but is used as established context. The specific contribution of the present study concerns the kinetics of the subsequent chemical step (decomposition of the Ni(III)-HmP adduct). Thin-layer voltammetry gives
k=(
2±1
)×
10
−6
s
−1
[1], while an independent MATLAB kinetic simulation (ODE45) of the coupled electrochemical-chemical process reproduces this value with
ksim=2.8×
10
−6
, in agreement with the experimental rate constant within its reported uncertainty (
k=(
2±1
)×
10
−6
s
−1
), the agreement being further improved after a 25% thin-layer volume correction. This agreement between an independent numerical model and the experimental kinetics is the central new result of this study, and provides a validated computational framework for future refinement of K from potential-shift data, and for the design of nickel-based electrocatalytic sensors for histamine detection in fish.