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K. R. Sheeja, G. Kuttan and R. Kuttan, “Cytotoxic and Antitumour Activity of Berberin,” Amala Research Bulletin, Vol. 17, 1997, pp. 73-76.

has been cited by the following article:

• TITLE: Synthesis of Some New Arylazothiophene and Arylazopyrazole Derivatives as Antitumor Agents

  AUTHORS: Ahmed Ali Fadda, E. Abdel-Latif, Rasha E. El-Mekawy

  KEYWORDS: Benzoylacetone; Phenylisothiocyanate; Thiophene; Pyrazole; Thiocarbamoyl; Cytotoxic Agents

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.3 No.2, April 25, 2012

  ABSTRACT: The starting 1-phenylbutane-1,3-dione (1) was used as key intermediate for the synthesis of several new thiophene and pyrazole derivatives. The newly synthesized compounds were evaluated for in vitro cytotoxicity against an Ehrlich ascites cells and in vivo cytotoxicity for compound 10d using EAC assay and 5-fluorouracil is used as reference drug. Compounds 7c, e and 10c, d showed significant activity in certain cancer cell and have been targeted for further studies, compound 10d is more effective and showed the highest activity. Structures of the newly prepared compounds were confirmed by both spectral, analytical data and molecular calculations.