TITLE:
Synthesis of Some New Arylazothiophene and Arylazopyrazole Derivatives as Antitumor Agents
AUTHORS:
Ahmed Ali Fadda, E. Abdel-Latif, Rasha E. El-Mekawy
KEYWORDS:
Benzoylacetone; Phenylisothiocyanate; Thiophene; Pyrazole; Thiocarbamoyl; Cytotoxic Agents
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.3 No.2,
April
25,
2012
ABSTRACT: The starting 1-phenylbutane-1,3-dione (1) was used as key intermediate for the synthesis of several new thiophene and pyrazole derivatives. The newly synthesized compounds were evaluated for in vitro cytotoxicity against an Ehrlich ascites cells and in vivo cytotoxicity for compound 10d using EAC assay and 5-fluorouracil is used as reference drug. Compounds 7c, e and 10c, d showed significant activity in certain cancer cell and have been targeted for further studies, compound 10d is more effective and showed the highest activity. Structures of the newly prepared compounds were confirmed by both spectral, analytical data and molecular calculations.