TITLE:
Performance of the FMF First-Trimester Preeclampsia Screening Model and Aspirin Prophylaxis Outcomes in Vietnam: A Prospective Cohort Study
AUTHORS:
Truong Huu Cuong, Bui Minh Cuong, Nguyen Thanh Mai, Nguyen Thu Huong, Vu Thi Huyen, Do Duy Long, Nguyen Van Khanh
KEYWORDS:
Preeclampsia, First-Trimester Screening, FMF Model, Aspirin Prophylaxis
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.16 No.9,
September
17,
2026
ABSTRACT: Early identification of women at high risk of preeclampsia enables timely preventive interventions, particularly low-dose aspirin prophylaxis. This prospective cohort study evaluated the performance of the Fetal Medicine Foundation (FMF) first-trimester screening model and assessed pregnancy outcomes following aspirin prophylaxis among singleton pregnancies between 11 weeks 3 days and 13 weeks 6 days of gestation at a tertiary center in Vietnam from November 2023 to November 2025. Screening integrated maternal characteristics, mean arterial pressure, uterine artery pulsatility index, and placental growth factor, with high-risk women receiving targeted aspirin prophylaxis (150 mg daily). Among 1187 analyzed pregnancies, 84 women (7.1%) were classified as high risk. The overall incidence of preeclampsia was 0.9%, with no cases occurring before 34 weeks of gestation. Preeclampsia was significantly associated with a lower gestational age at delivery, reduced birth weight, and higher rates of neonatal intensive care unit admission. Overall, the integration of the FMF first-trimester screening model with targeted aspirin prophylaxis demonstrated high feasibility and effectiveness, yielding favorable maternal and neonatal outcomes and supporting its broader implementation in clinical practice in Vietnam.